The German National Node, represented by the Comprehensive Childhood Research Center (CCRC Hauner) at LMU Klinikum Munich, delivers a specialised contribution in paediatric data science, artificial intelligence, and computational translational research, advancing digital approaches for precision medicine and data-driven healthcare while strengthening capabilities in federated analytics, clinical-omics integration, and advanced digital infrastructures for paediatric research.
The core activity is the integration, management, and analysis of large-scale clinical and multi-omics datasets through advanced computational infrastructures. CCRC Hauner combines state-of-the-art genomics technologies with high-performance computing resources, enabling the development, validation, and deployment of AI-based solutions for paediatric research. Its infrastructure includes large-scale genomic sequencing platforms, secure clinical data environments, federated learning capabilities, and dedicated computational systems for machine learning and data-intensive analyses. A major strength of the centre is the integration of heterogeneous clinical, molecular, and omics datasets into a Clinical Knowledge Graph framework, facilitating semantic interoperability, data harmonisation, and advanced knowledge discovery. This environment supports the development of predictive models, biomarker identification, patient stratification approaches, and decision-support tools across a broad spectrum of paediatric diseases. CCRC Hauner also provides specialised services in data preprocessing, federated model development, AI algorithm design, machine learning consultancy, and knowledge graph integration. These capabilities enable collaborative research across institutions while maintaining data privacy and regulatory compliance. The infrastructure supports applications in diagnostics, precision medicine, translational research, and real-world evidence generation within paediatric populations.