Paediatric Medicines Discovery TRP

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The EPTRI TRP on Paediatric Medicines Discovery provides a unified, fully equipped and competent organisation composed of research units that work in a concerted way toward the early-stage discovery and development of druggable molecular targets specific to paediatric disease, as well as discover new drugs using models reproducing specific paediatric ontogenetic stages.

EPTRI combines basic and applied research spanning in interdisciplinary fields like medicinal chemistry, structural biology, advanced developmental science and animal models to facilitate drug development directly focusing on paediatric populations and not through extrapolation from corresponding studies on adults.

Services are:

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In vitro screening of novel drugs using paediatric cellular targets.
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In vitro pre-clinical studies (effect, efficacy, biomarkers, etc.) in paediatric cell models

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Access to the neonatal and juvenile animal models to screen novel drug for a paediatric specific target.
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Access to the neonatal and juvenile animal models to perform preclinical studies.
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In silico screening of novel drugs for specific paediatric targets
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In silico prediction of ADME properties & toxicity for new molecular entity of paediatrics interest
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Scientific advice on specific research questions