Case study 1 – Wearable multiplexed biosensor for cyanotic congenital heart disease
Cyanotic congenital heart disease (CCHD) refers to a heterogeneous group of congenital heart defects characterized by hypoxemia due to shunting of blood. The main symptoms of cyanosis are associated with a bluish discoloration of skin and mucous membranes and clubbing of fingers and toes. Congenital heart disease (CHD) affects 8 to 9 per 1000 live births, and approximately 25% are considered CCHD. Depending on the degree of severity, heart defects such as CCHD may require surgery or catheter intervention to repair the defects or redirect blood flow. In children with unrepaired heart defects from several months up to 2 years of age sudden episodes of profound cyanosis and hypoxia may occur, which may be lethal. It has been observed that patients with low arterial oxygen tensions, reduced oxygen uptake developed a significant lactic acidosis. For this reason, the assessment of acid-base status for the immediate determination of cyanotic congenital heart disease is essential.
Main goals
The OrphaDev4Kids Project will support the development of a wearable multiplexed biosensor for the prevention of lactic acidosis in children with unrepaired congenital heart defects and/or the monitoring and evaluation of the physiologic response to pulmonary valve replacement in children with repaired congenital heart defects. The proposed MD will assess the blood acid-base status and arterial oxygen tension: analysis of lactate, pyruvate levels and their ratio, will provide the assessment on oxygen consumption, and based on these analyses prompt interventions can be taken in the clinical setting. The proposed MD is at a very early stage of the development process and the idea was suggested by an academic group.
Survey on Cyanotic Congenital Heart Disease (CCHD)
The survey seeks to collect valuable feedback to refine the development of the wearable multiplexed biosensor tailored for patients with Cyanotic Congenital Heart Disease (CCHD). It is specifically designed to gather insights ensuring that the device meets technical, usability, and clinical effectiveness requirements.
Key details:
- Anonymity: data collection is entirely anonymous; no personal data and identifiers will be processed.
- Duration: completing the survey takes approximately 20 minutes.
Who is the survey for?
- Clinicians and Researchers specializing in CCHD.
- Caregivers of individuals with CCHD.
- Clinicians and Researchers not specializing in CCHD but willing to provide their insightful feedback.
Your support is of great importance to ensure a successful development of the wearable multiplexed biosensor tailored for patients with Cyanotic Congenital Heart Disease (CCHD). For further questions or information, please contact Roberta Nossa at [email protected].