Dr Lederer is Senior Scientist and Head of the Molecular Genetics Thalassaemia Department (MGTD) at the Cyprus Institute of Neurology & Genetics (CING), as well as Associate Professor and course and programme coordinator of the CING Postgraduate School. He is executive board member of the National Committee for Thalassemia, the Global Globin Network, the Human Variome Project (HVP), and the European Paediatric Translational Research Infrastructure (EPTRI), member of the core-development team of the ITHANET Portal, and member of the ClinGen-recognised Hemoglobinopathies Variant Curation Expert Panel. As author of 55 peer-reviewed articles with over 3100 literature citations he has an h index of 25 (i10 index 41).
Key activities in his department include (i) translational research for the discovery of biomarkers and disease modifiers, (ii) population-wide diagnostics, clinical hematology and preimplantation genetic testing for a range of genetic disorders, (iii) bioinformatic development of databases, patient registries, variant curation and epidemiology, (vi) education and training in research and diagnostic techniques and concepts of rare blood disorders, and (v) gene editing and advanced therapy development for rare blood disorders and in particular β-thalassemia.
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