Developmental Pharmacology TRP

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The Developmental Pharmacology TRP is aimed to develop an alternative and comprehensive, paediatric approach in which the knowledge of growth and development/maturation of the organs and functions are fundamental premises to study pharmacological characteristic of a drug and body response.

Laboratory tests and methods proposed in the Platform are specific for each paediatric age since they are focusing on children maturation changes with growth that affect drug disposition and efficacy and toxicity through all the paediatric ages.

The TRP also deal with the placental research to address pharmacological research questions during pregnancy and the perinatal stage.

Services are:

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Microdosing to establish the “in vivo” PK profile of the new drug.

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In vitro models to study ontogeny of drug disposition.

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Placental studies.

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In vivo toxicity juvenile animal studies.

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Paediatric ADME and modelling and simulation.

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Sensitive analytical methods adapted to paediatrics.