Pharmacometrics modelling and extrapolation of posology from adults to children
This service provides pharmacometrics support using Model-Informed Drug Development (MIDD) to guide paediatric dose selection. Services include developing Population Pharmacokinetic (PopPK) models in adults to quantify drug exposure and variability, then extrapolating to children through allometric scaling and integration of developmental ontogenies. Pharmacometrics methods also characterise PK/PD variability and strengthen dose rationale and benefit–risk assessment. Expertise is offered in paediatric PK/PD integration, including optimal sampling time points and advanced modelling approaches such as physiology-based pharmacokinetics (PBPK) and PopPK models. Models support extrapolation across populations, compounds and conditions, maximising use of existing evidence.
