Paediatric Disease Characterisation Services
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Integrated structural biology and biophysical/omics approaches for molecular disease characterisation
This set of services apply structural biology techniques to characterise the 3D structures of proteins and RNA involved in paediatric diseases at atomic resolution which ensure molecular characterisation aligned with the unique physiology and clinical needs of children. Structural data provide critical insights into molecular function, the impact of mutations, and potential targets for diagnostics and therapeutics.
AI- and structure-enabled approaches for paediatric drug discovery from target identification to hit-to-lead optimisation
This set of services offer a an integrated set of structural, computational, and biophysical techniques to initiate the first phase of therapeutics development.
Integrated multi-omics approaches for paediatric biomarker discovery and validation
These services are based on advanced multi-omics approaches to identify and characterise molecular changes during disease development, enabling early diagnostics and insights into progression. Analyses include genomics, epigenetics, transcriptomics, proteomics, lipidomics, metabolomics, and microbiome studies, all adapted to paediatric physiology for clinically relevant biomarker discovery.